Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAD | Q92934 | 14/20 | 0.38 |
| ▸ | BCL2 | P10415 | 11/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.36 |
| ▸ | MARK3 | P27448 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.34 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.34 |
| ▸ | NEK4 | P51957 | 2/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25786206 | 0.95 | BAD (0.35) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786208 | 0.87 | MARK3 (0.34) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786210 | 0.86 | BAD (0.36) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786203 | 0.85 | BAD (0.41) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25249630 | 0.83 | PDE6D (0.30) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL29897071 | 0.83 | PDE6D (0.30) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786617 | 0.82 | BAD (0.45) | BADBCL2BCL2L1MCL1PMAIP1 | |
| SCHEMBL25786202 | 0.81 | BAD (0.40) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786214 | 0.81 | BAD (0.40) | BADBCL2BCL2L1MARK3GSK3B | |
| SCHEMBL25786204 | 0.81 | BAD (0.38) | BADBCL2BCL2L1MARK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | MCL1, BCL2A1, BCL2L1 | BAD 20/4885BCL2 10/4885BCL2L1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.