Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 9/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.33 |
| ▸ | BCL2 | P10415 | 6/20 | 0.33 |
| ▸ | MARK3 | P27448 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 2/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.32 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | NEK4 | P51957 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25786244 | 0.88 | BAD (0.33) | MCL1BADBCL2L1BCL2MARK3 | |
| SCHEMBL25786240 | 0.87 | KDM4E (0.37) | MCL1BADBCL2L1BCL2MARK3 | |
| SCHEMBL25293250 | 0.87 | TP53 (0.35) | MCL1KDM4EALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL25786239 | 0.86 | MAPK8 (0.35) | BADBCL2L1BCL2MARK3SYK | |
| SCHEMBL25786236 | 0.85 | MARK3 (0.35) | MCL1BADBCL2L1BCL2MARK3 | |
| SCHEMBL25786221 | 0.78 | MARK3 (0.39) | MCL1MARK3SYKGSK3BPLK1 | |
| SCHEMBL25786220 | 0.77 | MARK3 (0.37) | MCL1MARK3SYKGSK3BPLK1 | |
| SCHEMBL25786217 | 0.75 | MARK3 (0.41) | MCL1PIN1MARK3SYKGSK3B | |
| SCHEMBL25248815 | 0.74 | TP53 (0.35) | MAPK8KDM4EALDH1A1 | |
| SCHEMBL25246284 | 0.74 | TP53 (0.36) | MAPK8KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | MCL1, BCL2A1, BCL2L1 | MCL1 1/4885PIN1 1955/4885BAD 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.