Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996514 | 0.73 | HCAR2 (0.37) | TSHRCA12CA1CA2MMP1 | |
| SCHEMBL24514907 | 0.69 | MGAM (0.35) | TSHRGAA | |
| SCHEMBL26401927 | 0.67 | SMN1; SMN2 (0.48) | ALDH1A1GAA | |
| SCHEMBL13257985 | 0.67 | CA12 (0.33) | TSHRCA12CA1CA2MMP1 | |
| SCHEMBL24751602 | 0.65 | TSHR (0.32) | TSHRCA12CA1CA2MMP1 | |
| SCHEMBL21533286 | 0.64 | — | — | |
| SCHEMBL23989298 | 0.63 | TSHR (0.31) | TSHR | |
| SCHEMBL22427298 | 0.63 | — | — | |
| SCHEMBL19737848 | 0.63 | — | — | |
| SCHEMBL19354637 | 0.63 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634417-B1 | QUINAZOLINE-PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES INC (US) | 2023-07-12 | — | — | EP | disclosed |