SCHEMBL25786348

SCHEMBL25786348

C[Si](C)(C)CCOCn1ccc2c(Cl)c(C3CCC(O)C3)cnc21

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 6/20 0.33
MAPT P10636 1/20 0.31
PDE10A Q9Y233 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30539174 1.00 DGAT1 (0.33) DGAT1MAPTPDE10A
SCHEMBL30539237 0.88 DGAT1 (0.35) DGAT1PDE10A
SCHEMBL30539190 0.82 NPC1 (0.31) DGAT1MAPT
SCHEMBL25786349 0.82 NPC1 (0.31) DGAT1MAPT
SCHEMBL25786673 0.78 DGAT1 (0.38) DGAT1MAPT
SCHEMBL30539152 0.78 DGAT1 (0.38) DGAT1MAPTPDE10A
SCHEMBL30539251 0.78 DGAT1 (0.38) DGAT1MAPT
SCHEMBL16977995 0.76 DGAT1 (0.38) DGAT1MAPT
SCHEMBL18547508 0.75 DGAT1 (0.38) DGAT1MAPT
SCHEMBL1565433 0.75 DGAT1 (0.40) DGAT1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023168686-A1 SUBSTITUTED CYCLOPENTANES AS CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2023-09-14 WO disclosed
WO-2023116884-A1 CDK2 INHIBITORS AND USE THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2023-06-29 WO disclosed