SCHEMBL25786359

SCHEMBL25786359

CCn1nc(C)cc1C(=O)Nc1nc2cc(C(N)=O)cc(OCCCOC)c2n1CCCNC(=O)OCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 20/20 1.00
IRF3 Q14653 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19449091 0.93 STING1 (1.00) STING1IRF3
SCHEMBL22135280 0.91 STING1 (0.89) STING1IRF3
SCHEMBL22135231 0.91 STING1 (0.89) STING1IRF3
SCHEMBL22135012 0.90 STING1 (1.00) STING1IRF3
SCHEMBL22135219 0.90 STING1 (0.90) STING1IRF3
SCHEMBL22135211 0.89 STING1 (1.00) STING1
SCHEMBL22135303 0.88 STING1 (0.87) STING1IRF3
SCHEMBL22135216 0.88 STING1 (0.91) STING1
SCHEMBL21648072 0.87 STING1 (0.89) STING1IRF3
SCHEMBL22135076 0.87 STING1 (1.00) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210968-A1 RIBONUCLEOPROTEIN APPROACH TO BOOST THE STING SIGNALING FOR CANCER IMMUNOTHERAPY MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-07-06 US disclosed
US-20230210968-A1 RIBONUCLEOPROTEIN APPROACH TO BOOST THE STING SIGNALING FOR CANCER IMMUNOTHERAPY MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-07-06 US disclosed
CN-112279835-B Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof 中国医学科学院药物研究所 2022-07-22 CN disclosed
CN-112279835-A Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof 中国医学科学院药物研究所 2021-01-29 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210968-A1 RIBONUCLEOPROTEIN APPROACH TO BOOST THE STING SIGNALING FOR CANCER IMMUNOTHERAPY STING1, IRF3, MAVS STING1 1/4885IRF3 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.