Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.32 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20779640 | 0.95 | TEAD1 (0.52) | TEAD1YAP1TNNI3KARSMN1; SMN2 | |
| SCHEMBL22646187 | 0.87 | TEAD1 (0.43) | TEAD1YAP1TNNI3KARSMN1; SMN2 | |
| SCHEMBL20779643 | 0.79 | TEAD1 (0.59) | TEAD1YAP1TNNI3KSMN1; SMN2KMT2A | |
| SCHEMBL25790320 | 0.77 | TEAD1 (0.43) | TEAD1YAP1TNNI3KSMN1; SMN2KMT2A | |
| SCHEMBL20779713 | 0.76 | TEAD1 (0.52) | TEAD1YAP1TNNI3KSMN1; SMN2KMT2A | |
| SCHEMBL25789977 | 0.76 | TEAD1 (0.55) | TEAD1YAP1TNNI3KMAPTALDH1A1 | |
| SCHEMBL29901822 | 0.76 | TEAD1 (0.64) | TEAD1YAP1TNNI3KKMT2AMEN1 | |
| SCHEMBL20766874 | 0.76 | TEAD1 (0.64) | TEAD1YAP1TNNI3KKMT2AMEN1 | |
| SCHEMBL25787720 | 0.74 | KMT2A (0.42) | SMN1; SMN2KMT2ALMNAMEN1MAPT | |
| SCHEMBL25787758 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2KMT2ALMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | TEAD1 1/4885YAP1 9/4885TNNI3K 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.