SCHEMBL2579369

SCHEMBL2579369

O=C=Nc1cccc(Cc2cccc(N=C=O)c2Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.50
GABRB2 P47870 3/20 0.50
CYP3A4 P08684 4/20 0.48
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 2/20 0.33
MAPK1 P28482 1/20 0.33
PNMT P11086 1/20 0.32
TRPA1 O75762 1/20 0.32
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11234939 0.89 GABRA1 (0.50) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL18701450 0.84 CYP3A4 (0.50) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL15544 0.84 CYP3A4 (0.50) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL29404189 0.84 CYP3A4 (0.50) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL58545 0.83 CYP3A4 (0.60) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL9174101 0.82 GABRA1 (0.38) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL1396494 0.82 CYP3A4 (0.48) GABRA1GABRB2CYP3A4TSHRTDP1
Formaldehyde SCHEMBL8766988 0.80 CYP3A4 (0.47) GABRA1GABRB2CYP3A4TSHRTDP1
SCHEMBL23721618 0.79 GABRA1 (0.58) GABRA1GABRB2CYP3A4TSHRTRPA1
SCHEMBL17504402 0.79 GABRA1 (0.58) GABRA1GABRB2CYP3A4TSHRTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048493-B2 Method of forming piezoelectric resin film KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2011-11-01 US disclosed
US-20080008825-A1 Method of forming piezoelectric resin film KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2008-01-10 US disclosed
US-4663416-A Novel condensation polymers containing units from 8,9-bis(hydroxyalkyl)-exo-3,4,5-trithiatricyclo[5.2.1.02,6 ]decane THE DOW CHEMICAL COMPANY (US) 1987-05-05 US disclosed
US-4165412-A SALTS OF TERTIARY AMINE AND ALPHA-SUBSTITUTED CARBOXYLIC ACIDS AIR PRODUCTS AND CHEMICALS, INC. (US) 1979-08-21 US disclosed
US-4077921-A PHENOLIC MICROBALLOONS, AMINE CURING AGENT, SOLVENT, SPACECRAFT THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1978-03-07 US disclosed