Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 5/20 | 0.56 |
| ▸ | ARAF | P10398 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590020 | 0.92 | BRAF (0.58) | BRAFKDRHDAC1HDAC3HDAC4 | |
| SCHEMBL2579421 | 0.89 | KDR (0.74) | BRAFKDRRAF1 | |
| SCHEMBL2582322 | 0.87 | BRAF (0.62) | BRAFKDRHDAC1HDAC3HDAC4 | |
| SCHEMBL2584007 | 0.87 | BRAF (0.62) | BRAFKDRHDAC1HDAC3HDAC4 | |
| SCHEMBL2579543 | 0.86 | BRAF (0.61) | BRAFKDRHDAC1HDAC3HDAC4 | |
| SCHEMBL2581374 | 0.83 | KDR (0.65) | BRAFKDRRAF1RET | |
| SCHEMBL2581543 | 0.80 | BRAF (0.55) | BRAFKDRRAF1RET | |
| SCHEMBL2579573 | 0.80 | BRAF (0.55) | BRAFKDRRAF1RET | |
| SCHEMBL4475606 | 0.79 | BRAF (1.00) | BRAF | |
| SCHEMBL2576492 | 0.77 | RAF1 (0.54) | BRAFKDRRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | claimed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | claimed |
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | disclosed |
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | disclosed |
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | disclosed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | disclosed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | disclosed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | NRAS, SFPQ, TYR | BRAF 29/4885KDR 1517/4885HDAC1 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.