Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.74 |
| ▸ | BRAF | P15056 | 8/20 | 0.65 |
| ▸ | CDK8 | P49336 | 3/20 | 0.60 |
| ▸ | RAF1 | P04049 | 1/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581374 | 0.94 | KDR (0.65) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL2579416 | 0.89 | BRAF (0.65) | KDRBRAFRAF1 | |
| SCHEMBL2577878 | 0.87 | KDR (0.70) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL2583862 | 0.86 | KDR (0.69) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL282044 | 0.85 | KDR (1.00) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL2590020 | 0.83 | BRAF (0.58) | KDRBRAFCDK8RAF1 | |
| SCHEMBL16621015 | 0.83 | KDR (0.70) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL2936061 | 0.83 | KDR (0.69) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL16620824 | 0.81 | KDR (0.65) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL2577906 | 0.81 | KDR (0.62) | KDRBRAFCDK8RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | claimed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | claimed |
| US-8049014-B2 | Aminoquinoline derivatives, preparation method thereof and pharmaceutical composition comprising the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-11-01 | — | — | US | disclosed |
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KP) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249182-A1 | AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | NRAS, SFPQ, TYR | KDR 1517/4885BRAF 29/4885CDK8 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.