SCHEMBL25795113

SCHEMBL25795113

Cn1cc(Cl)c2cc(C(=O)NCCc3ccc(N4CCNCC4)cc3)cnc21

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
USP28 Q96RU2 18/20 0.48
USP25 Q9UHP3 16/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30741124 0.90 USP28 (0.47) USP28USP25
SCHEMBL21685997 0.90 USP28 (0.47) USP28USP25
SCHEMBL25795108 0.87 USP28 (0.46) USP28USP25
SCHEMBL21710328 0.83 USP28 (0.51) USP28USP25
SCHEMBL21710408 0.83 USP28 (0.50) USP28USP25
SCHEMBL31457117 0.83 USP28 (0.50) USP28USP25
SCHEMBL21710332 0.78 USP28 (0.50) USP28USP25
SCHEMBL21710323 0.76 USP28 (0.51) USP28USP25
SCHEMBL31457121 0.75 SMN1; SMN2 (0.52)
SCHEMBL21685903 0.75 SMN1; SMN2 (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023122298-A1 PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS Stablix, Inc. (US) 2023-06-29 WO disclosed