Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.39 |
| ▸ | BMP4 | P12644 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19481915 | 1.00 | RET (0.41) | RETIDH1KHKTDP1RUVBL1 | |
| SCHEMBL19458948 | 0.93 | TDP1 (0.45) | RETKHKTDP1RUVBL1BMP4 | |
| SCHEMBL25155062 | 0.92 | RET (0.39) | RETKHKRUVBL1BMP4KDR | |
| SCHEMBL19481702 | 0.90 | MAPT (0.44) | RETKHKTDP1RUVBL1BMP4 | |
| SCHEMBL19481966 | 0.89 | MAPK8 (0.41) | RETIDH1TDP1RUVBL1 | |
| SCHEMBL19486471 | 0.89 | MAPK8 (0.41) | RETIDH1TDP1RUVBL1 | |
| SCHEMBL19486349 | 0.89 | RET (0.39) | RETIDH1TDP1RUVBL1ALDH1A1 | |
| SCHEMBL19481975 | 0.89 | RET (0.39) | RETIDH1TDP1RUVBL1ALDH1A1 | |
| SCHEMBL19481798 | 0.84 | BMP4 (0.40) | RETKHKRUVBL1BMP4KDR | |
| SCHEMBL19481916 | 0.84 | RET (0.37) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442977-B1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORP (US) | 2023-06-28 | — | — | EP | disclosed |