SCHEMBL2579682

SCHEMBL2579682

Cc1cnc2[nH]cc(Cc3cnc(Nc4cccnc4C(F)(F)F)nc3)c2c1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 13/20 0.59
CYP2C9 P11712 8/20 0.59
CYP2C19 P33261 3/20 0.54
CSF1R P07333 1/20 0.43
KIT P10721 1/20 0.43
BRD4 O60885 1/20 0.41
MET P08581 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2585775 0.82 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19
SCHEMBL2543533 0.79 CYP2C19 (0.65) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL2540324 0.77 CYP2C19 (0.57) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL2540030 0.77 CYP3A4 (0.62) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL1883190 0.76 CYP2C19 (0.81) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL2538827 0.75 CYP3A4 (0.52) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL1884922 0.75 CYP3A4 (0.70) CYP3A4CYP2C9CYP2C19CSF1RKIT
SCHEMBL2537798 0.75 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19CSF1RBRD4
SCHEMBL1883211 0.75 CYP3A4 (0.71) CYP3A4CYP2C9CYP2C19MET
SCHEMBL1883624 0.75 CYP3A4 (0.76) CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2560972-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR Plexxikon, Inc. (US) 2013-02-27 EP disclosed
WO-2011133637-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2011-10-27 WO disclosed