Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 19/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25780979 | 0.92 | ATF4 (0.48) | ATF4NPC1RAB9A | |
| SCHEMBL19568245 | 0.91 | ATF4 (0.46) | ATF4 | |
| SCHEMBL25812918 | 0.90 | ATF4 (0.45) | ATF4 | |
| SCHEMBL25781360 | 0.90 | ATF4 (0.45) | ATF4 | |
| SCHEMBL20992782 | 0.89 | ATF4 (0.45) | ATF4 | |
| SCHEMBL25812698 | 0.88 | ATF4 (0.46) | ATF4 | |
| SCHEMBL20992248 | 0.88 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19568854 | 0.88 | ATF4 (0.47) | ATF4 | |
| SCHEMBL25812756 | 0.87 | ATF4 (0.46) | ATF4 | |
| SCHEMBL20992457 | 0.87 | ATF4 (0.42) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |