Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 18/20 | 0.72 |
| ▸ | NLRP3 | Q96P20 | 11/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25797901 | 0.90 | IL1B (0.71) | IL1BNLRP3KCNH2 | |
| SCHEMBL25797821 | 0.86 | IL1B (0.70) | IL1BNLRP3 | |
| SCHEMBL25797700 | 0.84 | IL1B (0.73) | IL1BNLRP3 | |
| SCHEMBL31329532 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL22654964 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL31329541 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL22654962 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL31329515 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL22654995 | 0.83 | IL1B (1.00) | IL1BNLRP3KCNH2 | |
| SCHEMBL25798125 | 0.83 | IL1B (0.67) | IL1BNLRP3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |