Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 11/20 | 0.56 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 10/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798051 | 0.89 | LRRK2 (0.61) | IL1BEGLN2LRRK2NLRP3 | |
| SCHEMBL25798263 | 0.88 | IL1B (0.61) | IL1BNLRP3 | |
| SCHEMBL26773994 | 0.87 | IL1B (0.69) | IL1BLRRK2NLRP3 | |
| SCHEMBL25799047 | 0.87 | IL1B (0.54) | IL1BEGLN2LRRK2NLRP3 | |
| SCHEMBL25798115 | 0.86 | IL1B (0.62) | IL1BNLRP3 | |
| SCHEMBL25798524 | 0.86 | IL1B (0.59) | IL1BNLRP3 | |
| SCHEMBL25798378 | 0.85 | IL1B (0.55) | IL1BEGLN2LRRK2NLRP3 | |
| SCHEMBL25798314 | 0.85 | IL1B (0.58) | IL1BNLRP3 | |
| SCHEMBL25798119 | 0.84 | IL1B (0.57) | IL1BNLRP3 | |
| SCHEMBL25798321 | 0.84 | IL1B (0.57) | IL1BNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |