Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 15/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580155 | 1.00 | PIM1 (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL2578055 | 0.93 | PIM1 (0.35) | PIM1PIM2PIM3 | |
| SCHEMBL2578052 | 0.93 | PIM1 (0.35) | PIM1PIM2PIM3 | |
| SCHEMBL2582150 | 0.93 | PIM1 (0.35) | PIM1PIM2PIM3 | |
| SCHEMBL27890512 | 0.85 | PIM1 (0.40) | PIM1PIM2PIM3 | |
| SCHEMBL2564052 | 0.85 | PIM2 (0.40) | PIM1PIM2PIM3 | |
| SCHEMBL27906986 | 0.85 | PIM1 (0.40) | PIM1PIM2PIM3 | |
| SCHEMBL2520248 | 0.80 | PIM1 (0.40) | PIM1PIM2PIM3 | |
| SCHEMBL2519526 | 0.80 | PIM1 (0.40) | PIM1PIM2PIM3 | |
| SCHEMBL2580400 | 0.80 | PIM1 (0.40) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760857-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045461-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |
| EP-2556066-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124580-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-13 | — | — | WO | disclosed |