Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578052 | 1.00 | PIM1 (0.35) | PIM1PIM2PIM3MAP4K4MCHR1 | |
| SCHEMBL2578055 | 1.00 | PIM1 (0.35) | PIM1PIM2PIM3MAP4K4MCHR1 | |
| SCHEMBL2580153 | 0.93 | PIM1 (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL2580155 | 0.93 | PIM1 (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL2566137 | 0.84 | MAP4K4 (0.38) | PIM1PIM2PIM3MAP4K4MCHR1 | |
| SCHEMBL2522549 | 0.81 | PIM1 (0.36) | PIM1PIM2PIM3 | |
| SCHEMBL2578141 | 0.81 | PIM1 (0.36) | PIM1PIM2PIM3 | |
| SCHEMBL2520690 | 0.81 | PIM1 (0.36) | PIM1PIM2PIM3 | |
| SCHEMBL2519748 | 0.79 | PIM1 (0.39) | PIM1PIM2PIM3MAP4K4 | |
| SCHEMBL2521770 | 0.78 | PIM1 (0.36) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556066-B1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |
| EP-2556066-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124580-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-13 | — | — | WO | disclosed |