SCHEMBL25802078

SCHEMBL25802078

C=C(Cc1nc(-c2ccc(OCc3ccccc3)cc2)no1)C(=O)OC(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 5/20 0.50
▸ PPARD Q03181 5/20 0.48
▸ PPARA Q07869 5/20 0.48
▸ NPC1 O15118 2/20 0.48
▸ RAB9A P51151 2/20 0.48
▸ CASP3 P42574 1/20 0.48
▸ SENP8 Q96LD8 1/20 0.48
▸ SENP7 Q9BQF6 1/20 0.48
▸ SENP6 Q9GZR1 1/20 0.48
▸ SMPD1 P17405 3/20 0.48
▸ MAPK1 P28482 2/20 0.47
▸ TDP1 Q9NUW8 2/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ GSTP1 P09211 3/20 0.47
▸ TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23578031 0.87 FFAR1 (0.56) FFAR1PPARDPPARANPC1RAB9A
SCHEMBL23588077 0.85 ACACB (0.52) FFAR1NPC1RAB9ASMN1; SMN2
SCHEMBL30689348 0.83 IP6K1 (0.41) PPARDPPARAGSTP1TSHR
SCHEMBL25802137 0.82 MAPT (0.50) FFAR1MAPK1TDP1SMN1; SMN2TSHR
SCHEMBL25801756 0.81 TSHR (0.55) NPC1RAB9ASMN1; SMN2GSTP1TSHR
SCHEMBL25802130 0.81 TP53 (0.42) NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL25802125 0.81 MEN1 (0.46) NPC1RAB9ATDP1SMN1; SMN2L3MBTL1
SCHEMBL25807565 0.81 TP53 (0.42) NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL23588102 0.79 SPHK1 (0.48) FFAR1NPC1RAB9ATDP1SMN1; SMN2
SCHEMBL23578358 0.79 TP53 (0.40) NPC1RAB9ASMN1; SMN2GSTP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
EP-4081511-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES Sitryx Therapeutics Limited (GB) 2022-11-02 — — EP disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 FFAR1 1711/4885PPARD 1017/4885PPARA 1223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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