Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25804240 | 0.93 | ATF4 (0.51) | ATF4 | |
| SCHEMBL22956153 | 0.91 | ATF4 (0.40) | ATF4ALDH1A1GAAHCRTR1HCRTR2 | |
| SCHEMBL19556074 | 0.87 | ATF4 (0.52) | ATF4 | |
| SCHEMBL22628203 | 0.85 | ATF4 (0.42) | ATF4ALDH1A1GAAHCRTR1HCRTR2 | |
| SCHEMBL22956127 | 0.84 | ATF4 (0.49) | ATF4 | |
| SCHEMBL22669465 | 0.83 | ATF4 (0.39) | ATF4ALDH1A1GAA | |
| SCHEMBL19555443 | 0.80 | ATF4 (0.51) | ATF4 | |
| SCHEMBL19556397 | 0.80 | ATF4 (0.61) | ATF4 | |
| SCHEMBL22628172 | 0.78 | ATF4 (0.51) | ATF4 | |
| SCHEMBL19556366 | 0.78 | ATF4 (0.54) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |