Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569389 | 0.91 | ATF4 (0.72) | ATF4ALDH1A1GAA | |
| SCHEMBL19555985 | 0.89 | ATF4 (0.62) | ATF4ALDH1A1GAA | |
| SCHEMBL19569514 | 0.89 | ATF4 (0.61) | ATF4ALDH1A1GAA | |
| SCHEMBL20973977 | 0.88 | ATF4 (0.71) | ATF4ALDH1A1GAA | |
| SCHEMBL22668959 | 0.88 | ATF4 (0.71) | ATF4ALDH1A1GAA | |
| SCHEMBL30075935 | 0.85 | ATF4 (0.60) | ATF4ALDH1A1GAAKDM4ELMNA | |
| SCHEMBL19555380 | 0.85 | ATF4 (0.57) | ATF4ALDH1A1GAA | |
| SCHEMBL22397093 | 0.85 | ATF4 (0.63) | ATF4ALDH1A1GAA | |
| SCHEMBL30025947 | 0.85 | ATF4 (0.63) | ATF4ALDH1A1GAA | |
| SCHEMBL19555519 | 0.84 | ATF4 (0.56) | ATF4ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |