Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.81 |
| ▸ | BRD2 | P25440 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.80 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623578 | 0.94 | BRD4 (0.70) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL22443010 | 0.94 | BRD4 (0.70) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL19464042 | 0.90 | BRD4 (0.86) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL19463886 | 0.89 | BRD4 (1.00) | BRD4BRD2KCNH2BRD3BRDT | |
| Abbv-744 SCHEMBL19463409 | 0.89 | BRD4 (1.00) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL30693825 | 0.88 | BRD4 (0.77) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL19463232 | 0.88 | BRD4 (1.00) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL21652829 | 0.88 | BRD4 (0.74) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL19463119 | 0.87 | BRD4 (1.00) | BRD4BRD2KCNH2BRD3BRDT | |
| SCHEMBL21652758 | 0.87 | BRD4 (0.62) | BRD4BRD2KCNH2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4460302-A2 | COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2024-11-13 | — | — | EP | disclosed |
| EP-4274583-A2 | METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2023133284-A2 | COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2023-07-13 | — | — | WO | disclosed |
| WO-2023133284-A2 | COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2023-07-13 | — | — | WO | disclosed |