Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.70 |
| ▸ | PARP1 | P09874 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376478 | 0.89 | PTGS1 (0.55) | PTGS1PTGS2PARP1MAPTCXCR1 | |
| SCHEMBL31477369 | 0.85 | PTGS1 (0.72) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL9030430 | 0.85 | PTGS1 (0.72) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL31455828 | 0.85 | PTGS1 (0.77) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL8754918 | 0.83 | PTGS1 (1.00) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL577323 | 0.83 | PTGS1 (1.00) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL12935378 | 0.83 | PTGS1 (1.00) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL9086931 | 0.83 | PTGS1 (1.00) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| SCHEMBL14661109 | 0.83 | PARP1 (0.50) | PTGS1PTGS2PARP1SMN1; SMN2PARP10 | |
| SCHEMBL11132637 | 0.81 | PTGS1 (0.70) | PTGS1PTGS2PARP1MAPTCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219961-A1 | Pyridine acetamide derivative serving as CDK inhibitor, and preparation method therefor and use thereof | Suzhou Alphama Biotechnology Co., Ltd. (CN) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219961-A1 | Pyridine acetamide derivative serving as CDK inhibitor, and preparation method therefor and use thereof | CDK9, CDK7, CDK8 | PTGS1 1205/4885PTGS2 2365/4885PARP1 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.