Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 15/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051659 | 0.84 | GHSR (0.70) | GHSRTP53POLB | |
| SCHEMBL7840414 | 0.81 | GHSR (0.63) | GHSRTP53MAPTPOLB | |
| SCHEMBL5050576 | 0.80 | GHSR (0.63) | GHSRHTR1ADRD3OPRK1HTR3A | |
| SCHEMBL6178849 | 0.79 | GHSR (0.64) | GHSRTP53MAPTPOLB | |
| SCHEMBL6180297 | 0.78 | GHSR (0.60) | GHSRTP53MAPT | |
| SCHEMBL6177564 | 0.78 | GHSR (0.62) | GHSRTP53MAPTPOLB | |
| SCHEMBL17521418 | 0.76 | GHSR (0.58) | GHSRTP53MAPT | |
| SCHEMBL2579878 | 0.76 | GHSR (0.72) | GHSRHTR1ADRD3OPRK1HTR3A | |
| SCHEMBL6181657 | 0.75 | GHSR (0.59) | GHSRTP53MAPT | |
| SCHEMBL6178340 | 0.75 | GHSR (0.59) | GHSRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389941-A1 | Growth-hormone secretagogues | Elixir Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| EP-1781311-A2 | GROWTH-HORMONE SECRETAGOGUES | Elixir Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006023608-A2 | GROWTH-HORMONE SECRETAGOGUES | ELIXIR PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |