SCHEMBL2581351

SCHEMBL2581351

C=CC(=O)O[Si](C)(C)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.41
AKT1 P31749 1/20 0.39
MAPT P10636 1/20 0.39
TGM2 P21980 2/20 0.36
THRA P10827 1/20 0.35
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
PDE6D O43924 1/20 0.32
TSHR P16473 1/20 0.31
GSTO1 P78417 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10890696 0.85 THRB (0.41) THRBAKT1MAPTTGM2THRA
SCHEMBL9411666 0.85 THRB (0.41) THRBAKT1MAPTTGM2THRA
SCHEMBL28365493 0.85 MAPT (0.41) AKT1MAPTESR1ESR2ALDH1A1
SCHEMBL28365580 0.85 MAPT (0.41) AKT1MAPTESR1ESR2ALDH1A1
SCHEMBL28959321 0.81 THRB (0.43) THRBAKT1MAPTTGM2THRA
SCHEMBL21925797 0.81 THRB (0.43) THRBAKT1MAPTTGM2THRA
SCHEMBL5142114 0.81 THRB (0.43) THRBAKT1MAPTTGM2THRA
SCHEMBL2577811 0.81 THRB (0.38) THRBAKT1MAPTTGM2THRA
SCHEMBL17754532 0.80 THRB (0.37) THRBAKT1MAPTTGM2THRA
SCHEMBL22398867 0.79 MAPT (0.40) THRBAKT1MAPTESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4593055-A Binder contains acrylated ester M&T CHEMICALS INC. (US) 1986-06-03 US claimed
EP-4267708-B1 THERMALLY RESPONSIVE BRUSH POLYMERS HAVING A COPOLYMER BACKBONE AND COPOLYMER ARMS INFINEUM INT LTD (GB) 2025-07-02 EP disclosed
US-12281203-B2 Thermally responsive brush polymers having a copolymer backbone and copolymer arms INFINEUM INTERNATIONAL LIMITED (GB) 2025-04-22 US disclosed
US-20240309155-A1 Thermally Responsive Brush Polymers Having a Copolymer Backbone and Copolymer Arms INFINEUM INTERNATIONAL LIMITED (GB) 2024-09-19 US disclosed
EP-4267708-A1 THERMALLY RESPONSIVE BRUSH POLYMERS HAVING A COPOLYMER BACKBONE AND COPOLYMER ARMS Infineum International Limited (GB) 2023-11-01 EP disclosed
CN-116981758-A Thermally responsive brush polymers having a copolymer backbone and copolymer arms 英菲诺姆国际有限公司 2023-10-31 CN disclosed
WO-2022136384-A1 THERMALLY RESPONSIVE BRUSH POLYMERS HAVING A COPOLYMER BACKBONE AND COPOLYMER ARMS INFINEUM INTERNATIONAL LIMITED (GB) 2022-06-30 WO disclosed
US-20210277257-A1 Paint system with anti-fouling character EVONIK OPERATIONS GMBH (DE) 2021-09-09 US disclosed
CN-113354972-A Paint system with antifouling properties 赢创运营有限公司 2021-09-07 CN disclosed
CN-107429083-B Paint system containing antifouling metal oxide and fumed silica 赢创德固赛有限公司 2020-03-13 CN disclosed
EP-1080640-B1 COATED BIS(2-PYRIDINETHIOL-1-OXIDE)COPPER SALT API CORP (JP) 2003-09-10 EP disclosed
US-20030124085-A1 Coated bis (2-pyridinethiol-1-oxide) copper salt API CORPORATION (JP) 2003-07-03 US disclosed
US-6544440-B1 Antifouling active ingredient for a coating for the bottom of a ship, which is safe during handling; rosin coated; biocides API CORPORATION (JP) 2003-04-08 US disclosed
EP-0942018-B1 (METH)ACRYLIC ESTER COPOLYMERS AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2003-03-12 EP disclosed
EP-1227111-A1 TRIPHENYLBORON-CONTAINING POLYMERS AND USE THEREOF Yoshitomi Fine Chemicals, Ltd. (JP) 2002-07-31 EP disclosed
US-6218485-B1 LIVING ANIONIC POLYMERIZATION USING AN ORGANIC ALKALI METAL AND/OR AN ALKALI METAL AS A POLYMERIZATION INITIATOR, WHEREIN A TARGET MOLECULAR WEIGHT IS OBTAINED BY ADDING THE COMPOUND DIVIDED INTO MULTIPLE STEPS. NIPPON SODA CO., LTD. (JP) 2001-04-17 US disclosed
EP-1080640-A1 COATED BIS(2-PYRIDINETHIOL 1-OXIDE) COPPER SALT Yoshitomi Fine Chemicals, Ltd. (JP) 2001-03-07 EP disclosed
EP-0942018-A1 (METH)ACRYLIC ESTER COPOLYMERS AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1999-09-15 EP disclosed
WO-1991014743-A1 ANTIFOULING COATING COMPOSITIONS COURTAULDS COATINGS (HOLDINGS) LIMITED (GB) 1991-10-03 WO disclosed
US-4593055-A Binder contains acrylated ester M&T CHEMICALS INC. (US) 1986-06-03 US disclosed