Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199352 | 0.87 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| Methane SCHEMBL2581414 | 0.83 | SMN1; SMN2 (0.54) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2203090 | 0.81 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2199284 | 0.79 | MAPT (0.59) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6824979 | 0.79 | MAPK14 (0.77) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2197054 | 0.78 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL1903401 | 0.78 | MAPK14 (0.78) | MAPK13MAPK12MAPK11MAPK14AVPR2 | |
| SCHEMBL2203132 | 0.78 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2199250 | 0.77 | NPC1 (0.59) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2195814 | 0.76 | AVPR2 (0.64) | MAPK13MAPK12MAPK11MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658263-B9 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2011-11-09 | — | — | EP | claimed |
| EP-1658263-B1 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2010-06-02 | — | — | EP | claimed |