Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CBS | P35520 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199352 | 0.85 | MAPK13 (0.63) | SMN1; SMN2NPC1RAB9AHTTMAPK14 | |
| SCHEMBL2581412 | 0.83 | MAPK13 (0.58) | SMN1; SMN2NPC1RAB9AHTTMAPK14 | |
| SCHEMBL2199284 | 0.78 | MAPT (0.59) | SMN1; SMN2NPC1RAB9AHTTMAPK14 | |
| SCHEMBL2197054 | 0.77 | MAPK13 (0.55) | MAPK14MAPK13MAPK12MAPK11GRIK1 | |
| SCHEMBL2203132 | 0.76 | MAPK13 (0.54) | SMN1; SMN2NPC1RAB9AMAPK14MAPK13 | |
| SCHEMBL2199250 | 0.75 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AHTTMAPK14 | |
| SCHEMBL2200476 | 0.75 | MAPK13 (0.57) | NPC1RAB9AMAPK14MAPK13MAPK12 | |
| SCHEMBL5753034 | 0.75 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11GAA | |
| SCHEMBL2203090 | 0.74 | MAPK13 (0.59) | SMN1; SMN2NPC1RAB9AMAPK14MAPK13 | |
| SCHEMBL2199258 | 0.74 | MAPK14 (0.55) | SMN1; SMN2NPC1RAB9AMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658263-B9 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2011-11-09 | — | — | EP | claimed |
| EP-1658263-B1 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2010-06-02 | — | — | EP | claimed |