Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 4/20 | 0.58 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25825194 | 0.82 | USP28 (0.67) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25808859 | 0.79 | USP28 (0.73) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25794464 | 0.78 | USP28 (0.72) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25810028 | 0.76 | USP28 (0.75) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23683179 | 0.74 | USP28 (1.00) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31464215 | 0.74 | USP28 (1.00) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29841090 | 0.74 | USP28 (1.00) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25794463 | 0.73 | USP28 (0.69) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23683171 | 0.73 | USP28 (0.75) | USP28USP25MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25794179 | 0.73 | USP28 (0.74) | USP28USP25MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |