Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 18/20 | 0.69 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.69 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816369 | 0.91 | PBRM1 (0.56) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25816134 | 0.83 | PBRM1 (0.74) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL38663471 | 0.83 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL29936408 | 0.83 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18038799 | 0.83 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30606976 | 0.82 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18081005 | 0.82 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL23037205 | 0.82 | PBRM1 (0.97) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18081211 | 0.79 | PBRM1 (0.65) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25815627 | 0.79 | PBRM1 (0.49) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |