Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 18/20 | 0.56 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.56 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816154 | 0.91 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL25816318 | 0.85 | PBRM1 (0.65) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL25816414 | 0.81 | CRBN (0.48) | — | |
| SCHEMBL18081213 | 0.81 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL25816134 | 0.77 | PBRM1 (0.74) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL21673580 | 0.76 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL30606976 | 0.76 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL18081005 | 0.76 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL25816349 | 0.76 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL23303332 | 0.75 | PBRM1 (0.59) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |