Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 16/20 | 0.65 |
| ▸ | SMARCA2 | P51531 | 13/20 | 0.65 |
| ▸ | SMARCA4 | P51532 | 13/20 | 0.65 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816134 | 0.93 | PBRM1 (0.74) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL25816369 | 0.85 | PBRM1 (0.56) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30667399 | 0.81 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL18038763 | 0.81 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL23303172 | 0.80 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29910647 | 0.80 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL23303211 | 0.79 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29910480 | 0.79 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL18080991 | 0.78 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL22776923 | 0.78 | SMARCA2 (0.67) | PBRM1SMARCA2SMARCA4BRD4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |