Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040634 | 0.90 | KDM4E (0.66) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL11890502 | 0.87 | KDM4E (0.73) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL1387066 | 0.87 | KDM4E (0.80) | KDM4ETSHRPRKACARPS6KB1GSK3B | |
| SCHEMBL11890510 | 0.87 | KDM4E (0.52) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL1386481 | 0.85 | KDM4E (0.71) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL1387031 | 0.85 | KDM4E (0.74) | KDM4ETSHRTP53SMN1; SMN2PRKACA | |
| SCHEMBL1385523 | 0.85 | KDM4E (0.71) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL5040782 | 0.84 | ALDH1A1 (0.55) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL1386316 | 0.83 | BCHE (0.68) | KDM4ETSHRBCHETP53SMN1; SMN2 | |
| SCHEMBL2579670 | 0.82 | KDM4E (0.66) | KDM4ETSHRBCHETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42890-E1 | Furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2011-11-01 | — | — | US | claimed |
| US-7385061-B2 | 4-[1-(6-amino-3-pyridylcarbonylmethyl)-1H-benzimidazol-2-yl]-furazan-3-yl]-N-(2-cyanoethyl)-amine; treatment of neoplastic and autoimmune diseases | BASILEA PHARMACEUTICA AG (CH) | 2008-06-10 | — | — | US | claimed |
| EP-1636215-B1 | FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2008-01-23 | — | — | EP | claimed |
| EP-1636215-B1 | FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2008-01-23 | — | — | EP | disclosed |