Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23021427 | 0.82 | TDP1 (0.43) | KMT2AMEN1ALDH1A1PDK1PDK2 | |
| SCHEMBL20021746 | 0.77 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL19500998 | 0.71 | KMT2A (0.55) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL19105239 | 0.70 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL12128693 | 0.70 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL2241428 | 0.70 | KMT2A (0.57) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL20934725 | 0.70 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL14783691 | 0.70 | KMT2A (0.57) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL14855865 | 0.70 | KMT2A (0.57) | KMT2AMEN1ALDH1A1PTPN1PTPRC | |
| SCHEMBL20844053 | 0.69 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | NEK7, NEK1, NEK5 | KMT2A 2881/4885MEN1 1800/4885ALDH1A1 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.