Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663163 | 0.89 | ALOX15 (0.61) | KDM4EMAPTALOX15HSD17B10PTGS1 | |
| SCHEMBL29379822 | 0.82 | ALOX15 (0.47) | KDM4EMAPTALOX15HSD17B10PTGS1 | |
| SCHEMBL22323779 | 0.82 | ALOX15 (0.47) | KDM4EMAPTALOX15HSD17B10PTGS1 | |
| SCHEMBL22323723 | 0.79 | PTGS1 (0.51) | KDM4EMAPTALOX15HSD17B10PTGS1 | |
| SCHEMBL12325496 | 0.78 | ALOX15 (0.43) | KDM4EMAPTALOX15HSD17B10POLB | |
| SCHEMBL13672151 | 0.78 | KDM4E (0.50) | KDM4EMAPTALOX15HSD17B10POLB | |
| SCHEMBL22950970 | 0.74 | CSNK2A2 (0.62) | KDM4EMAPTALOX15HSD17B10POLB | |
| SCHEMBL1500217 | 0.74 | HSD17B3 (0.61) | KDM4EMAPTALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL29379868 | 0.74 | HSD17B3 (0.61) | KDM4EMAPTALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL24166096 | 0.74 | KDM4E (0.40) | KDM4EMAPTALOX15HSD17B10PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |