Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24163113 | 0.92 | MAPT (0.46) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL26409412 | 0.86 | MAPT (0.50) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL15730121 | 0.84 | KDM4E (0.52) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL29109563 | 0.79 | KDM4E (0.44) | MAPTKDM4EALDH1A1NSD2HPGD | |
| SCHEMBL30665076 | 0.77 | ALDH1A1 (0.55) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL15515928 | 0.77 | MAPT (0.46) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL25104925 | 0.76 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL25105491 | 0.76 | MAPT (0.44) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| Hydrochloric Acid SCHEMBL31600876 | 0.76 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1NSD2NOTUM | |
| SCHEMBL23643838 | 0.76 | MAPT (0.44) | MAPTKDM4EALDH1A1NSD2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |