Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509772 | 1.00 | PARP1 (0.42) | PARP1ALOX12TAAR1TYK2NPC1 | |
| SCHEMBL12221753 | 0.76 | PARP1 (0.40) | PARP1TAAR1KMT2A | |
| SCHEMBL2509581 | 0.75 | PARP1 (0.39) | PARP1TAAR1NPC1RAB9A | |
| SCHEMBL8034264 | 0.75 | NPC1 (0.34) | ALOX12TYK2NPC1RAB9AKMT2A | |
| SCHEMBL12263337 | 0.74 | PIK3CG (0.44) | — | |
| SCHEMBL5859162 | 0.72 | KDM4E (0.39) | NPC1RAB9AKMT2ADRD4 | |
| SCHEMBL2504431 | 0.71 | PIK3CD (0.53) | — | |
| SCHEMBL524001 | 0.67 | TAAR1 (0.68) | PARP1ALOX12TAAR1NPC1RAB9A | |
| SCHEMBL12737571 | 0.67 | TAAR1 (0.68) | PARP1ALOX12TAAR1NPC1RAB9A | |
| SCHEMBL8330903 | 0.67 | TAAR1 (0.68) | PARP1ALOX12TAAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |