Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochlorthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL27890005 | 0.98 | FFAR3 (0.33) | — | |
| Hydrochlorthiazide SCHEMBL15571830 | 0.95 | FFAR3 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL15573119 | 0.95 | FFAR3 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL27521699 | 0.95 | FFAR3 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL353307 | 0.93 | FFAR3 (0.30) | — | |
| Hydrochlorthiazide SCHEMBL15656554 | 0.92 | — | — | |
| Hydrochlorthiazide SCHEMBL15510913 | 0.91 | — | — | |
| Hydrochlorthiazide SCHEMBL4940467 | 0.90 | ALDH1A1 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL1422022 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL28321063 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102919799-B | Cream enzymolysis composition and preparation method thereof | DADHANK CHENGDU BIOTECH CO LTD | 2014-06-25 | — | — | CN | claimed |
| CN-102919799-A | Cream enzymolysis composition and preparation method thereof | DADHANK CHENGDU BIOTECH CO LTD | 2013-02-13 | — | — | CN | claimed |
| CN-1492867-A | Thiazoleacetic thioester derivatives and their use in the preparation of cephalosporin compounds | �¿˵»�ѧҽҩƷ����˾ | 2004-04-28 | — | — | CN | claimed |
| EP-0477197-B1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID | UPJOHN CO (US) | 1995-07-12 | — | — | EP | claimed |
| CN-1073444-A | Cephalosporin compound and preparation method thereof | TANABE SEIYAKU CO (JP) | 1993-06-23 | — | — | CN | claimed |
| EP-0477197-A1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID. | UPJOHN CO (US) | 1992-04-01 | — | — | EP | claimed |
| CN-1014321-B | PROCESS FOR PRODUCING GLUTACONIC ACID DERIVATIVE | SHIONOGI & CO (JP) | 1991-10-16 | — | — | CN | claimed |
| WO-1990015802-A1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID | THE UPJOHN COMPANY (US) | 1990-12-27 | — | — | WO | claimed |
| EP-0318488-A4 | STIMULATION OF ANGIOGENESIS AND PROMOTION OF ENDOTHELIALISATION. | BIOTA SCIENT MANAGEMENT (AU) | 1990-02-26 | — | — | EP | claimed |
| EP-0294380-A4 | STIMULATION OF ANGIOGENESIS. | BIOTA SCIENT MANAGEMENT (AU) | 1990-02-20 | — | — | EP | claimed |
| EP-0318488-A1 | STIMULATION OF ANGIOGENESIS AND PROMOTION OF ENDOTHELIALISATION | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 1989-06-07 | — | — | EP | claimed |
| EP-0294380-A1 | STIMULATION OF ANGIOGENESIS | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 1988-12-14 | — | — | EP | claimed |
| WO-1988001166-A1 | STIMULATION OF ANGIOGENESIS AND PROMOTION OF ENDOTHELIALISATION | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 1988-02-25 | — | — | WO | claimed |
| WO-1987004925-A1 | STIMULATION OF ANGIOGENESIS | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 1987-08-27 | — | — | WO | claimed |
| CN-85106433-A | Produce the method for glutaconic acid derivative | — | 1987-03-18 | — | — | CN | claimed |
| JP-9067354-A | — | — | None | — | — | JP | disclosed |
| JP-9067353-A | — | — | None | — | — | JP | disclosed |
| WO-1988001166-A1 | STIMULATION OF ANGIOGENESIS AND PROMOTION OF ENDOTHELIALISATION | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 1988-02-25 | — | — | WO | disclosed |
| CN-85106433-A | Produce the method for glutaconic acid derivative | — | 1987-03-18 | — | — | CN | disclosed |
| CN-85106433-A | Produce the method for glutaconic acid derivative | — | 1987-03-18 | — | — | CN | disclosed |