Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | ALB | P02768 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 2/20 | 0.32 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24637965 | 0.82 | LMNA (0.40) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13722573 | 0.78 | LMNA (0.38) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL12191308 | 0.77 | LMNA (0.36) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL4074704 | 0.75 | TYMP (0.33) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13864259 | 0.74 | LMNA (0.48) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL1097293 | 0.73 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19259067 | 0.73 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2767893 | 0.73 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL5557391 | 0.73 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10072463 | 0.73 | LMNA (0.41) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212572-A1 | Guanosine Analogues for Use in Therapeutics Polynucleotides | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-07-06 | — | — | US | disclosed |