Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23066157 | 0.82 | MAPK8 (0.41) | GABRA1GABRB2MAPK8MAPK9MAPK10 | |
| SCHEMBL24721906 | 0.79 | GABRA1 (0.39) | GABRA1GABRB2MTNR1BMTNR1APDE10A | |
| SCHEMBL31325769 | 0.79 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MTNR1BMTNR1A | |
| SCHEMBL31325676 | 0.79 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MTNR1BMTNR1A | |
| SCHEMBL31325737 | 0.76 | TAAR1 (0.43) | MAPK8MAPK9MAPK10MTNR1BMTNR1A | |
| SCHEMBL25820075 | 0.76 | CCNC (0.42) | — | |
| SCHEMBL18368376 | 0.76 | ALOX5AP (0.36) | GABRA1GABRB2MAPK10ALOX5APFEN1 | |
| SCHEMBL31325761 | 0.75 | MEN1 (0.41) | MAPK8MAPK9MAPK10MTNR1BMTNR1A | |
| SCHEMBL12749711 | 0.75 | KDM4E (0.48) | GABRA1GABRB2MEN1HTTKMT2A | |
| SCHEMBL20626988 | 0.74 | GABRA1 (0.43) | GABRA1GABRB2PDE10ACHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | GABRA1 3307/4885GABRB2 2323/4885MAPK8 126/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | GABRA1 3364/4885GABRB2 2245/4885MAPK8 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.