Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | ATR | Q13535 | 4/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820151 | 0.86 | TDP1 (0.44) | LRRK2 | |
| SCHEMBL25820105 | 0.84 | CLK1 (0.44) | LRRK2 | |
| SCHEMBL25820145 | 0.84 | SYK (0.38) | LRRK2SYKATRCDK4CCND1 | |
| SCHEMBL26329863 | 0.81 | LRRK2 (0.44) | LRRK2SYKATR | |
| SCHEMBL25821153 | 0.80 | PRKDC (0.43) | LRRK2 | |
| SCHEMBL26081274 | 0.80 | LRRK2 (0.38) | LRRK2SYKATRATRIPPDPK1 | |
| SCHEMBL25820104 | 0.80 | IP6K1 (0.48) | — | |
| SCHEMBL25820106 | 0.80 | IP6K1 (0.45) | — | |
| SCHEMBL25820118 | 0.79 | HRH4 (0.35) | — | |
| SCHEMBL25820121 | 0.79 | MAP4K4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | LRRK2 500/4885SYK 1886/4885ATR 863/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | LRRK2 820/4885SYK 1923/4885ATR 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.