Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23418795 | 0.85 | TNIK (0.41) | IDO1TGFBR1TNIKKDM4EMAPT | |
| SCHEMBL25822606 | 0.85 | TGFBR1 (0.44) | IDO1TGFBR1TNIKKDM4EMAPT | |
| SCHEMBL26003342 | 0.85 | IDO1 (0.63) | IDO1TNIKKDM4EMAPTPIK3CD | |
| SCHEMBL29796536 | 0.83 | TGFBR1 (0.43) | IDO1TGFBR1TNIKMAPK14TGFBR2 | |
| SCHEMBL23389618 | 0.83 | TGFBR1 (0.43) | IDO1TGFBR1TNIKMAPK14TGFBR2 | |
| SCHEMBL25822576 | 0.83 | TGFBR1 (0.43) | IDO1TGFBR1KDM4EMAPTPIK3CD | |
| SCHEMBL23392259 | 0.79 | TGFBR1 (0.44) | TGFBR1TNIKKDM4EMAPK14NPC1 | |
| SCHEMBL22075123 | 0.77 | IDO1 (0.60) | IDO1TGFBR1TNIKKDM4EMAPT | |
| SCHEMBL22074893 | 0.77 | TGFBR1 (0.48) | IDO1TGFBR1TNIKKDM4EMAPT | |
| SCHEMBL25822610 | 0.76 | NPC1 (0.36) | TGFBR1KDM4EMAPTPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218597-A1 | SUBSTITUTED PYRIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218597-A1 | SUBSTITUTED PYRIDINES AND METHODS OF USE | ALK, ACVR1, ACVR2A | IDO1 2343/4885TGFBR1 211/4885TNIK 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.