Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SOD1 | P00441 | 1/20 | 0.47 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18928532 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL24675642 | 0.88 | POLB (0.57) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9974699 | 0.83 | TSHR (0.65) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8349049 | 0.83 | TSHR (0.65) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL25823611 | 0.83 | POLB (0.56) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5251060 | 0.82 | KDM4E (0.63) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL15295402 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL20378856 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10801532 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL25815700 | 0.81 | CNR1 (0.47) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |