Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871232 | 0.85 | GRIA1 (0.38) | TK1MAPK1DAOALDH1A1CYP2C9 | |
| SCHEMBL21283135 | 0.85 | MAPK1 (0.33) | TK1SMN1; SMN2MAPK1DAOTDP1 | |
| SCHEMBL25823740 | 0.78 | DAO (0.37) | TK1DAOHPGDKDM4EALDH1A1 | |
| SCHEMBL27057530 | 0.77 | KDM4E (0.44) | TK1KDM4EALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL9910660 | 0.75 | MAPK1 (0.44) | TK1MAPK1HPGDALDH1A1 | |
| SCHEMBL35260 | 0.75 | SMN1; SMN2 (0.42) | TK1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23957853 | 0.73 | MAPK1 (0.43) | TK1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22873334 | 0.73 | TNKS (0.33) | DAOTDP1 | |
| SCHEMBL12724348 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ECYP1A2KMT2A | |
| SCHEMBL22817647 | 0.73 | DAO (0.32) | SMN1; SMN2DAOTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| US-20230220384-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-07-13 | — | — | US | disclosed |