SCHEMBL25823911

SCHEMBL25823911

CCc1ccc2c(c1)CC1(CCNC1)O2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HDAC3 O15379 3/20 0.38
HDAC4 P56524 3/20 0.38
HDAC1 Q13547 3/20 0.38
HDAC7 Q8WUI4 3/20 0.38
HDAC2 Q92769 3/20 0.38
HDAC10 Q969S8 3/20 0.38
HDAC11 Q96DB2 3/20 0.38
HDAC8 Q9BY41 3/20 0.38
HDAC6 Q9UBN7 3/20 0.38
HDAC9 Q9UKV0 3/20 0.38
HDAC5 Q9UQL6 3/20 0.38
PARP1 P09874 1/20 0.37
HTR2C P28335 3/20 0.33
HTR2A P28223 2/20 0.33
HTR2B P41595 2/20 0.33
IRAK4 Q9NWZ3 1/20 0.30
SLC5A1 P13866 1/20 0.30
SLC5A2 P31639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25823916 0.81 KDM4E (0.41) ATMHDAC3HDAC4HDAC1HDAC7
SCHEMBL4222971 0.78 HTR2C (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL31059137 0.78 HTR2C (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL25814380 0.78 HPGD (0.39) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11250972 0.78 HTR2A (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL29418152 0.74 OPRD1 (0.43) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11254844 0.74 OPRD1 (0.43) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL3226548 0.73 OPRD1 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8225530 0.72 HIF1A (0.44) ATML3MBTL1PARP1HTR2A
SCHEMBL8243703 0.72 ATM (0.45) ATML3MBTL1PARP1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125944-A1 COMPOUND CONTAINING HETEROCYCLIC RING 正大天晴药业集团股份有限公司 2023-07-06 WO disclosed