Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 6/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858212 | 0.87 | CDC7 (0.56) | ROCK1CYP3A4CDC7DYRK1ACLK4 | |
| SCHEMBL2558076 | 0.83 | KIT (0.45) | ROCK1CYP3A4CDC7DYRK1ACLK4 | |
| SCHEMBL2529574 | 0.79 | CDC7 (0.52) | ROCK1CYP3A4CDC7DYRK1ACLK4 | |
| SCHEMBL1044409 | 0.72 | ROCK2 (0.71) | ROCK1CDC7DYRK1ACLK4ROCK2 | |
| SCHEMBL1045939 | 0.71 | CDC7 (0.64) | ROCK1CYP3A4CDC7DYRK1ACLK4 | |
| SCHEMBL31064980 | 0.70 | CDC7 (0.70) | ROCK1CDC7DYRK1ACLK4ROCK2 | |
| SCHEMBL26174548 | 0.70 | CDC7 (0.49) | ROCK1CDC7DYRK1ACLK4ROCK2 | |
| SCHEMBL13887725 | 0.70 | ROCK1 (1.00) | ROCK1CYP3A4DYRK1ACDK2GSK3B | |
| SCHEMBL12763310 | 0.70 | KIT (0.66) | CDC7DYRK1AKITCLK1DYRK1B | |
| SCHEMBL14034363 | 0.69 | KDM4E (0.56) | TP53DHODHMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560971-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133388-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |
| EP-2560971-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133388-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |