Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31188115 | 1.00 | DDB1 (0.47) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL25263858 | 0.85 | EGLN1 (0.38) | — | |
| SCHEMBL25831682 | 0.83 | DDB1 (0.49) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL25831704 | 0.80 | DDB1 (0.42) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL25831131 | 0.80 | PDE4B (0.50) | DDB1CRBNHPGDSMAPTJAK2 | |
| SCHEMBL31017634 | 0.80 | PDE4B (0.50) | DDB1CRBNHPGDSMAPTJAK2 | |
| SCHEMBL25427387 | 0.79 | DDB1 (0.41) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL16048398 | 0.76 | KDM4E (0.53) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL30729914 | 0.76 | CNR1 (0.46) | DDB1CRBNHPGDSKDM4EMAPT | |
| SCHEMBL27309056 | 0.76 | CNR1 (0.46) | DDB1CRBNHPGDSKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118414336-A | Degradation of Bruton Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2024-07-30 | — | — | CN | disclosed |
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |