SCHEMBL2583210

SCHEMBL2583210

c1ccc(-c2nc(N3CCc4ccccc4C3)c3ccccc3n2)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 2/20 0.80
ACP1 P24666 2/20 0.65
ABCG2 Q9UNQ0 3/20 0.62
ALDH1A1 P00352 3/20 0.58
MAPT P10636 3/20 0.58
GAA P10253 1/20 0.58
TSHR P16473 4/20 0.56
MEN1 O00255 1/20 0.56
USP2 O75604 1/20 0.56
KMT2A Q03164 1/20 0.56
LMNA P02545 5/20 0.55
MAPK1 P28482 3/20 0.55
KDM4E B2RXH2 2/20 0.55
ACHE P22303 1/20 0.55
HSD17B10 Q99714 2/20 0.53
HTT P42858 1/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
TP53 P04637 1/20 0.52
HPGD P15428 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4094744 0.91 GBA1 (0.68) GBA1ACP1ABCG2ALDH1A1MAPT
SCHEMBL18353946 0.89 GBA1 (1.00) GBA1ALDH1A1MAPTGAATSHR
SCHEMBL4091848 0.83 ABCB1 (0.69) GBA1ALDH1A1MAPTGAATSHR
SCHEMBL12667623 0.83 METAP1 (0.67) GBA1ALDH1A1MAPTGAATSHR
SCHEMBL1085065 0.82 ABCG2 (0.88) ACP1ABCG2ALDH1A1MAPTTSHR
SCHEMBL3641040 0.82 GBA1 (0.59) GBA1ALDH1A1MAPTGAAMEN1
SCHEMBL3637720 0.80 L3MBTL1 (0.69) GBA1ACP1ALDH1A1GAATSHR
SCHEMBL4089260 0.79 ACP1 (1.00) ACP1ABCG2ALDH1A1MAPTGAA
SCHEMBL3638559 0.78 L3MBTL1 (0.72) GBA1ACP1ALDH1A1MAPTGAA
SCHEMBL6125247 0.78 TSHR (0.84) GBA1ACP1ABCG2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2566480-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE California Institute of Technology (US) 2013-03-13 EP disclosed
WO-2011140527-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) 2011-11-10 WO disclosed
WO-2011140527-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) 2011-11-10 WO disclosed