Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861782 | 0.84 | HTT (0.38) | EPHX2ALDH1A1HTTCYP2C19MEN1 | |
| SCHEMBL21105825 | 0.84 | HTT (0.38) | EPHX2ALDH1A1HTTCYP2C19MEN1 | |
| SCHEMBL22794812 | 0.84 | HTT (0.38) | EPHX2ALDH1A1HTTCYP2C19MEN1 | |
| SCHEMBL18880057 | 0.84 | HTT (0.38) | EPHX2ALDH1A1HTTCYP2C19MEN1 | |
| SCHEMBL22837644 | 0.84 | HTT (0.38) | EPHX2ALDH1A1HTTCYP2C19MEN1 | |
| SCHEMBL20231578 | 0.83 | ALDH1A1 (0.35) | EPHX2ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL3209063 | 0.80 | CYP2C19 (0.48) | ALDH1A1HTTCYP2C19MEN1KMT2A | |
| SCHEMBL20634245 | 0.80 | CYP2C19 (0.52) | ALDH1A1HTTCYP2C19MEN1KMT2A | |
| SCHEMBL4748879 | 0.80 | — | — | |
| SCHEMBL18551601 | 0.79 | ALDH1A1 (0.41) | EPHX2ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |