Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | QPCT | Q16769 | 2/20 | 0.49 |
| ▸ | QPCTL | Q9NXS2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254034 | 0.90 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL31050185 | 0.90 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL6004927 | 0.85 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL14669311 | 0.79 | QPCT (0.57) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL2569383 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL30822560 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL20847438 | 0.78 | QPCT (0.58) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL2686936 | 0.78 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL24684965 | 0.78 | QPCT (0.52) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL18610454 | 0.76 | QPCT (0.45) | NPC1RAB9ASMN1; SMN2QPCTQPCTL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | EGFR, ERBB2, ERBB4 | NPC1 1611/4885RAB9A 715/4885SMN1; SMN2 4575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.