Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.62 |
| ▸ | RAB9A | P51151 | 12/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | QPCT | Q16769 | 2/20 | 0.55 |
| ▸ | QPCTL | Q9NXS2 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31050185 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL6004927 | 0.94 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL25833149 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL14669311 | 0.88 | QPCT (0.57) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL30822560 | 0.88 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL2569383 | 0.88 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL20847438 | 0.87 | QPCT (0.58) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL2686936 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL24684965 | 0.86 | QPCT (0.52) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL1459333 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707868-B | Benzimidazole-substituted halogenated phenyl n-butylamidine-based compound and preparation method thereof | 山东福长药业有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-114874212-B | Preparation method of pentacyclic compound containing benzimidazole | 嘉兴学院 | 2023-04-21 | — | — | CN | disclosed |
| US-20220054715-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | UNIV EMORY (US) | 2022-02-24 | — | — | US | disclosed |
| US-20210371992-A1 | ELECTROCHEMICAL ORGANIC REACTION SETUP AND METHODS | PIRAMAL PHARMA LIMITED (IN) | 2021-12-02 | — | — | US | disclosed |
| US-11179501-B2 | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto | EMORY UNIVERSITY (US) | 2021-11-23 | — | — | US | disclosed |
| CN-111170947-A | Preparation method of telmisartan impurity J | 江苏中邦制药有限公司 | 2020-05-19 | — | — | CN | disclosed |
| US-20190224378-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | UNIV EMORY (US) | 2019-07-25 | — | — | US | disclosed |
| US-10286113-B2 | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto | EMORY UNIVERSITY (US) | 2019-05-14 | — | — | US | disclosed |
| US-20190023694-A1 | BROAD SPECTRUM ANTIBACTERIAL ACTIVITY OF NOVEL BISBENZIMIDAZOLES TARGETING TOPOISOMERASE IA AND THE SYNERGISTIC COMPOSITION OF BISBENZIMIDAZOLE WITH EFFLUX PUMP INHIBITORS AGAINST PATHOGENIC BACTERIA | TANDON, VIBHA (IN) | 2019-01-24 | — | — | US | disclosed |
| WO-2017125944-A1 | BROAD SPECTRUM ANTIBACTERIAL ACTIVITY OF NOVEL BISBENZIMIDAZOLES TARGETING TOPOISOMERASE IA AND THE SYNERGISTIC COMPOSITION OF BISBENZIMIDAZOLE WITH EFFLUX PUMP INHIBITORS AGAINST PATHOGENIC BACTERIA | JAWAHARLAL NEHRU UNIVERSITY (JNU) (IN) | 2017-07-27 | — | — | WO | disclosed |
| US-20160361470-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | UNIV EMORY (US) | 2016-12-15 | — | — | US | disclosed |
| US-9056887-B2 | Minor groove binder phosphoramidites and methods of use | ELITECH HOLDING B.V. (NL) | 2015-06-16 | — | — | US | disclosed |
| US-20140248372-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-09-04 | — | — | US | disclosed |
| WO-2013043529-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-03-28 | — | — | WO | disclosed |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | ELITECH HOLDING B.V. | 2013-01-31 | — | — | US | disclosed |
| US-20090124814-A1 | Process for preparing telmisartan | PERLMAN NURIT | 2009-05-14 | — | — | US | disclosed |
| US-7501448-B2 | Process for preparing telmisartan | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2009-03-10 | — | — | US | disclosed |
| EP-1699765-A1 | PROCESS FOR PREPARING TELMISARTAN | Teva Pharmaceutical Industries Ltd (IL) | 2006-09-13 | — | — | EP | disclosed |
| US-20060094883-A1 | high yields, low cost process; easy solvent extraction; nontoxic, safe, environmentally friendly, low boiling point organic solvents; 1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl is reacted with 4'bromomethyl-biphenyl-2-carboxylic acid alkyl ester; industrial scale; hydrolysis | TEVA PHARMACEUTICALS USA, INC. | 2006-05-04 | — | — | US | disclosed |
| WO-2006044648-A1 | PROCESS FOR PREPARING TELMISARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094883-A1 | high yields, low cost process; easy solvent extraction; nontoxic, safe, environmentally friendly, low boiling point organic solvents; 1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl is reacted with 4'bromomethyl-biphenyl-2-carboxylic acid alkyl ester; industrial scale; hydrolysis | AGT, ACE, REN | NPC1 4197/4885RAB9A 3835/4885SMN1; SMN2 2165/4885 |
| US-20090124814-A1 | Process for preparing telmisartan | AGT, ACE, REN | NPC1 3908/4885RAB9A 3005/4885SMN1; SMN2 1859/4885 |
| US-20160361470-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | PCNA, CD2BP2, BPGM | NPC1 3751/4885RAB9A 4497/4885SMN1; SMN2 3714/4885 |
| US-20190224378-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
| US-20190023694-A1 | BROAD SPECTRUM ANTIBACTERIAL ACTIVITY OF NOVEL BISBENZIMIDAZOLES TARGETING TOPOISOMERASE IA AND THE SYNERGISTIC COMPOSITION OF BISBENZIMIDAZOLE WITH EFFLUX PUMP INHIBITORS AGAINST PATHOGENIC BACTERIA | TOP2B, TOP2A, TOP1 | NPC1 591/4885RAB9A 2107/4885SMN1; SMN2 4180/4885 |
| US-20140248372-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
| US-20220054715-A1 | Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
| US-11179501-B2 | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
| US-10286113-B2 | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto | BMP4, SOST, BMP2 | NPC1 3847/4885RAB9A 479/4885SMN1; SMN2 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.