Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.31 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25833645 | 0.87 | HTR2A (0.35) | TRPM8GBA1AOC3HTR2AHRH1 | |
| SCHEMBL25832995 | 0.87 | MAPT (0.38) | SLC6A4SLC6A2RAB9APBKLMNA | |
| SCHEMBL25262042 | 0.82 | GBA1 (0.35) | TRPM8GBA1SLC6A4SLC6A2LMNA | |
| SCHEMBL25831633 | 0.82 | GBA1 (0.35) | TRPM8GBA1SLC6A4SLC6A2LMNA | |
| SCHEMBL25304349 | 0.81 | AOC3 (0.41) | TRPM8GBA1SLC6A4SLC6A2LMNA | |
| SCHEMBL25831631 | 0.81 | AOC3 (0.41) | TRPM8GBA1SLC6A4SLC6A2LMNA | |
| SCHEMBL25852597 | 0.80 | SLC6A4 (0.33) | SLC6A4SLC6A2RAB9APBKLMNA | |
| SCHEMBL25853272 | 0.80 | SLC6A2 (0.33) | SLC6A4SLC6A2PBKAOC3HTR2A | |
| SCHEMBL18713530 | 0.79 | USP2 (0.38) | TRPM8SLC6A2GPR139ALDH1A1KCNH2 | |
| SCHEMBL25609098 | 0.79 | TRPM8 (0.38) | TRPM8GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827637-B2 | Azaindole derivatives and their use as ERK kinase inhibitors | AGV DISCOVERY (FR) | 2023-11-28 | — | — | US | disclosed |
| US-20230227451-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827637-B2 | Azaindole derivatives and their use as ERK kinase inhibitors | MAPKAPK2, MAPK1, MAPK7 | TRPM8 3075/4885GBA1 4295/4885SLC6A4 2807/4885 |
| US-20230227451-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | MAPKAPK2, MAPK1, MAPK7 | TRPM8 3075/4885GBA1 4295/4885SLC6A4 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.